Poly(butylene succinate) fibrous dressings containing natural antimicrobial agents

Poly(butylene succinate) (PBSU) is a biodegradable and biocompatible synthetic aliphatic polyester, which has been used extensively in packaging, catering agriculture, more recently drug delivery bone cartilage repair. PBSU-based mats created by electrospinning show promise as wound dressing materials because of their good mechanical properties, high surface area-to-volume ratio increased levels porosity. In this work, we present the creation antimicrobial PBSU fibrous through incorporation natural food grade agents via blend electrospinning. Three types edible gums (namely arabic, karaya tragacanth), two essential oils (coriander lavender), one free fatty acid (linoleic acid) were added to containing chain extender effect on six clinically relevant pathogens was evaluated. Mats at highest concentration studied (7% w/v) showed some behaviour against S. aureus, E. hirae P. aeruginosa, whereas linoleic both concentrations tested (3% 5% gave strong reaction pyogenes. Gum arabic only gum that had considerable impact aureus. Furthermore, three enhanced properties polymer brought them closer those human skin, whilst all maintained biocompatibility when contacted with mouse fibroblasts. This for first time, shows great blended fibres skin substitute paves way towards bioactive cost effective dressings from renewable materials.